Assistant Professor

Department of Pharmaceutical Sciences
College of Pharmacy
Larkin University

Contact Information

Office: Room 2504

Office Phone: 305-760-7493

Email: shafez@ularkin.org

Office Hours: By Appointment

Education and Training

Ph.D.

Clinical and Experimental Therapeutics

University of Georgia

Athens, Georgia

B.Pharm.

Cairo University

Cairo, Egypt

Teaching Interests

Dr. Hafez’s teaching interest includes various Pharm.D. courses, such as Cardiovascular Diseases, Pharmacokinetics, Neurologic and Psychiatric Disorders.

Scholarly Interests

Dr. Hafez’s research focuses on studying the impact of hyperglycemia on stroke outcomes, and on investigating the underlying mechanisms through which hyperglycemia exacerbates the neurovascular injury and worsens the functional outcomes after stroke. Dr. Hafez pointed out matrix metalloprotease 3 as a critical mediator of hemorrhagic transformation in hyperglycemic stroke. Dr. Hafez is also interested in developing novel non-pharmacological therapeutic approaches, like exercise and remote ischemic conditioning, to be employed in stroke therapy to reduce the injury and improve the outcomes.

Selected Publications

Hafez S, Abdelsaid M, El-Shafey S, Johnson MH, Fagan SC, Ergul A. Matrix Metalloproteinase 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke. Stroke 47: 843-851 (2016)

Hafez S, Ergul A. Response to Letter Regarding Article, “Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke”. Stroke 47: e173 (2016)

Hafez S, Hoda MN, Guo X, Johnson MH, Fagan SC, Ergul A. Comparative Analysis of Different Methods of Ischemia/Reperfusion in Hyperglycemic Stroke Outcomes: Interaction with tPA. Translational Stroke Research 6: 171-180 (2015)

Hafez S, Coucha M, Bruno A, Fagan SC, Ergul A. Hyperglycemia, Acute Ischemic Stroke and Thrombolytic Therapy. Translational Stroke Research 5: 442-453 (2014)

Selected Recent Presentations

Hafez S, Khan MB, Wagner JD, Hess DC. Short Term Acute Preconditioning Exercise Improves Stroke Outcomes and Reduces Neurovascular Injury via Increased eNOS Activity. International Stroke Conference, Houston, TX, February 22-24, 2017.

Hafez S, Khan MB, Wagner JD, Hess DC. Preconditioning Exercise Reduces Neurological deficits and Neurovascular Injury after Stroke through Increased Endothelial Nitric Oxide Synthase Activity. Southern Translational Education and Research Conference, Athens, GA, September 22-23, 2016.

Hafez S, Abdelsaid M, El-Shafey S, Fagan SC, Ergul A. Focal Knockdown of Matrix Metalloprotease 3 Reduces Hemorrhagic Transformation and Improves Neurobehavioral Outcomes in Hyperglycemic Stroke. International Stroke Conference, Los Angeles, CA, February17-19, 2016.

Hafez S, Md Hoda MN, Guo X, Fagan SC, Ergul A. Low dose tissue plasminogen activator (tPA) amplifies vascular injury and worsens functional outcomes in acute hyperglycemic stroke independent of the model of reperfusion. International Stroke Conference, Nashville, TN, February 11-13, 2015.

Awards and Honors

The American Heart Association Greater Southeast Affiliate Predoctoral Fellowship (2013-2015)

Southern Translational Education and Research (STaR) Conference Best Post-Doctoral Award Runner-up, 2016

Young Investigator Award, International Stroke Conference, Nashville, TN, 2015

Southern Translational Education and Research (STaR) Conference Best Graduate Student Award, 2014