Associate Professor

Department of Pharmaceutical Sciences
College of Pharmacy
Larkin University

Contact Information

Office: Room 2514
Office Phone: 305-760-7479

Email: sdeb@ULarkin.org
Office Hours: TBA

Education and Training

B.Pharm.

Berhampur University

Orissa, India

M.Pharm.

University of Mumbai

Mumbai, India

Ph.D.

Pharmaceutical Sciences

University of British Columbia

Vancouver, Canada

Post-doctoral Fellowship

Vancouver Prostate Centre at Vancouver General Hospital

Vancouver, Canada

Teaching Interests

Dr. Deb’s teaching interests and experience include Pharmacology, Toxicology, Pharmacogenomics, and Pharmacokinetics with special emphasis on Drug Metabolism.

Scholarly Interests

Dr. Deb’s research is focused on the application of absorption, distribution, metabolism, excretion and toxicity (ADMET)-based principles to understand the disposition of vitamin D/other lipid derivatives and therapeutic agents in hormonal cancers and liver disorders. His work on cytochrome P450-related interactions of drugs and natural products with endobiotics and xenobiotics has highlighted the vital role of metabolic interactions in disease pathophysiology and experimental therapeutics. Dr. Deb is also interested in the use of in silico tools such as simulation of ADMET and their associated interactions in pharmacokinetic and pharmacodynamic (PK-PD) modelling. Dr. Deb has keen interest in the utilization of pharmacogenomics concepts in unraveling drug interaction and drug action outcomes in patients.

Selected Recent Publications

Mannargudia B, Deb S. Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: Is it a viable cancer therapy? Journal of Cancer Research and Clinical Oncology 143:1499-1529 (2017)

Ben-Eltriki M, Deb S, Adomat H, Guns ES. Calcitriol and 20(S)-protopanaxadiol synergistically inhibit growth and induce apoptosis in human prostate cancer cells. Journal of Steroid Biochemistry and Molecular Biology 158:207-219 (2016)

Deb S, Chin MY, Adomat H, Guns ES. Ginsenoside-mediated blockade of 1α,25-dihydroxyvitamin D3 inactivation in human liver and intestine in vitro. Journal of Steroid Biochemistry and Molecular Biology 141:94-103 (2014)

Pham S, Deb S, Ming DS, Adomat H, Hosseini-Beheshti E, Zoubeidi A, Gleave M, Guns ES. Next-generation steroidogenesis inhibitors, dutasteride and abiraterone, attenuate but still do not eliminate androgen biosynthesis in 22RV1 cells in vitro. Journal of Steroid Biochemistry and Molecular Biology 144:436-444 (2014)

Ming DS, Pham S, Deb S, Chin MY, Kharmate G, Adomat H, Beheshti E, Locke J, Guns ES. Pomegranate extracts impact the androgen biosynthesis pathways in prostate cancer models in vitro and in vivo. Journal of Steroid Biochemistry and Molecular Biology 143:19-28 (2014)

Chiu NT, Guns ES, Adomat H, Jia W, Deb S.  Identification of human cytochrome P450 enzymes involved in the hepatic and intestinal biotransformation of 20(S) protopanaxadiol. Biopharmaceutics and Drug Disposition 35:104-118 (2014)

Publication list via PubMed:

https://www.ncbi.nlm.nih.gov/pubmed/?term=Deb+Subrata

Selected Recent Presentations

Interindividual variability in CYP3A activity: Influence on CYP3A-related herb-drug interactions from selected natural health supplements in human liver. Annual Meeting of American Society for Pharmacology and Experimental Therapeutics, Chicago, IL, April 22-26, 2017.

Metabolism in human prostate cancer tissue: Effect of CYP17 inhibitors. Annual Meeting of American Society for Pharmacology and Experimental Therapeutics, Chicago, IL, April 22-26, 2017.

Development of a robust HPLC method for midazolam hydroxylation assay: assessment of CYP3A4-mediated drug-herb interactions of selected polyphenols, furanocoumarin and terpenoids in human liver. American Association of Pharmaceutical Scientists Annual Meeting, Denver, CO, November 13-17, 2016.

Characterization of precursor-dependent steroidogenesis in human prostate cancer cells and tumor tissues. American Association of Pharmaceutical Scientists Annual Meeting, Denver, CO, November 13-17, 2016.

Impact of glucocorticoids on the bioavailability and metabolism of abiraterone and calcitriol. 6th World Congress on Bioavailability and Bioequivalence, Chicago, IL, August 17-19, 2015.

Simultaneous determination of murine cytochrome P450 activities in a cocktail assay using liquid chromatography/mass spectrometry. American Association of Pharmaceutical Scientists Annual Meeting, Orlando, FL, October 25-29, 2015.

Association of metabolic syndrome related biomarkers with hepatic function amongst adults in the United States: a cross sectional study. American Association of Pharmaceutical Scientists  Annual Meeting, Orlando, FL, October 25-29, 2015.

Phase I and phase II enzyme profile in a mouse xenograft model of LNCaP human prostate cancer. 45th Gordon Research Conference on Drug Metabolism, Holderness, NH, July 12-17, 2015.

Awards and Honors

Early Investigator Award (Society of Integrative Oncology, USA)

Michael Smith Foundation Postdoctoral Fellowship (Michael Smith Foundation for Health Research)

Jack Carlisle Founder’s Postdoctoral Award (Prostate Cancer Foundation of British Columbia)

Postdoctoral Research Fellowship (Prostate Cancer Foundation of British Columbia)

Douglas and Jean Bailey Scholarship (The University of British Columbia)

Associate Editor, Journal of Basic and Clinical Pharmacy