Research Foci

Dr. Chbib’s research goals are directed towards designing and synthesizing new molecules that might have therapeutic activities in different clinical fields. Her work centers around designing and synthesizing nucleoside analogues constructed with features that are chemically activated in the initial step of an enzyme mechanism where spontaneous subsequent reactions cause enzyme inactivation. Dr.  Chbib have developed several strategies for the synthesis of two novel classes of S-ribosylhomocysteine analogues which were designed as potential inhibitors of the S-ribosylhomocyteinase enzyme found in both Gram-positive and ‑negative bacteria. Her research interest also includes testing the synthesized analogues’ activity in vitro and determining their pharmacokinetic characteristics

Publications

  • Chbib, C., Gonzales, C., Mugdal, M., Nagaj, J., Stokowa-Soltys, K., Wnuk, Sobczak, A., S.F. S-ribosylhomocysteine Analogues Modified At The Ribosyl C-4 Position, J. Sulfur. Chem. 10: 1080, 2016. Dx.doi.org/10.1080/17415993.2015.1137921.
  • Sobzak, A., Chbib, C., Wnuk, S.F. S-ribosylhomocysteine Analogues Containing a [4-Thio-Ribose Ring, Res. 415: 39-47, 2015.
  • Saab Y.B., Kabbara W., Chbib C., Gard P.R. Buccal Cell DNA Extraction: Yield, Purity, and Cost: A Comparison of Two Methods, Genet. test. 11: 413-416, 2007.
  • Chbib C, Synthesis of isomeric analogues of S-ribosylhomocysteine analogues with homocysteine unit attached to C2 of ribose. Bioorg. Med .Chem. Lett. 2017 Apr 15;27(8):1681-1685. doi: 10.1016/j.bmcl.2017.03.004.