Research Foci

Dr Elgebaly’s expertise is in cardiovascular complications of diabetes mellitus in stroke. He earned his PhD from the University of Georgia Athens (UGA) from the program of Clinical and Experimental Therapeutics using a translational approach in his work. His area is biomarkers of neurovascular injury such understanding “Matrix Metalloproteinase -9 (MMP-9) Kinetic profile in diabetes and hyperglycemia and its role in worsening hemorrhagic stroke”. Dr Elgebaly proposes the use of multiplex assays and ELISAs to measure changes in MMP-9 expression and activity in mammalian-cultured cells exposed to hypoxic and hyperglycemic conditions. In addition, since he is interested in studying temporary focal ischemia which causes greater hemorrhagic transformation in diabetes secondary to increased cerebrovascular matrix metalloprotease (MMP) activity and tortuosity. This diabetes-induced cerebrovascular remodeling is MMP dependent. Prevention of vascular remodeling by glucose control or MMP inhibition reduces hemorrhagic transformation in diabetic stroke is a goal of his research. Vascular remodeling markers including MMP-9 activity in diabetes are the major focus of his studies.

Selected Publications

  1. Elgebaly MM, Ogbi S, Li W, Mezzetti EM, Prakash R, Johnson MH, Bruno A, Fagan SC, Ergul A. Neurovascular injury in acute hyperglycemia and diabetes: A comparative analysis in experimental stroke. Translational Stroke Research 2:391-398 (2011).
  1. Kelly-Cobbs AI, Harris AK, Elgebaly MM, Li W, Sachidanandam K, Portik-Dobos V, Johnson M, Ergul A. Endothelial endothelin B receptor-mediated prevention of cerebrovascular remodeling is attenuated in diabetes because of up-regulation of smooth muscle ET-1 receptors. J Pharmacol Exp Ther 337:9-15 (2011).
  2. Kelly-Cobbs A, Elgebaly MM, Li W, Ergul Pressure-independent cerebrovascular remodeling and changes in myogenic reactivity in diabetic Goto-Kakizaki rat in response to glycemic control. Acta Physiol (Oxf) 203:245-251 (2011).
  3. Elgebaly MM, Prakash R, Li W, Ogbi S, Johnson MH, Mezzetti EM, Fagan SC, Ergul A. Vascular protection in diabetic stroke: Role of matrix metalloprotease-dependent vascular remodeli J Cereb Blood Flow Metab 30:1928-1938 (2010).
  4. Ergul A, Li W, Elgebaly MM, Bruno A, Fagan SC. Hyperglycemia, diabetes and stroke: Focus on the cerebrovasculature. Vascul Pharmacol 51:44-49 (2009).
  5. Sachidanandam K, Hutchinson JR, Elgebaly MM, Mezzetti EM, Dorrance AM, Motamed K, Ergul A. Glycemic control prevents microvascular remodeling and increased tone in Type 2 diabetes:  Link to endothelin-1. Am J Physiol Regul Integr Comp Physiol 296:R952-959 (2009).